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Inhibits bacterial protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane Oral: 77% to 88% (Agwuh 2006); IM: Poor, with less than 60% of dose absorbed Widely distributed to most body fluids and tissues including ascitic, synovial and pleural fluids; bronchial secretions; poor penetration into CSF Urine (30%); feces (20% to 60%) (Agwuh 2006) Serum: Oral: 2 to 4 hours (Agwuh 2006) 6 to 11 hours (Agwuh 2006) 55% to 64% (Agwuh 2006) Because renal Cl is by glomerular filtration, excretion is snificantly affected by the state of renal function.

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(Pharmacology) an antibiotic synthesized from cortetracycline or derived from the bacterium Streptomyces viridifaciens: used in treating rickettsial infections and various bacterial infections.


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